George Herridge, 73, a retired hospital maintenance manager, told the Daily Mail he was 'stunned' to be twice asked by bus drivers to leave their vehicles because of his guide dog Andy, a black Labrador.
Mr Herridge, who lives with wife Janet, 69, in Tilehurst, Reading, said that on the first occasion two years ago, he got off at the request of a Muslim driver because some Muslim children on board were 'screaming' because of the dog.
He found himself in a similar scenario in May last year, when a Muslim woman and her children became 'hysterical'. Mr Herridge this time refused the driver's request to alight.
He complained to the bus company which launched an investigation. It later informed him the matter had been dealt with 'internally'.
Jill Allen-King, spokesman for the NFB, said she had been repeatedly left on the kerb by Muslim taxi drivers who refused to take her dog.
One cab driver told her he would have to 'go home now and wash myself' when she tried to enter his car with her dog.